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Development of a multiphasic material with continuous gradient for tissue engineering of the osteotendinous and myotendinous junctions

Autor*in: Nicolas Rivoallan

ISBN: 978-3-69030-136-7

Dissertation, Leibniz Universität Hannover, 2025

Herausgeber*in der Reihe: Birgit Glasmacher

Band-Nr.: IMP 04/2025

Umfang: 266 Seiten, 114 Abbildungen

Schlagworte: Tissue engineering, musculoskeletal system, electrospinning, photolithography

Kurzfassung: Tendons link muscle to bone, enabling movement, but heal poorly. To improve repair, researchers are developing engineered grafts mimicking bone-tendon-muscle interfaces. Unique structures at entheses and myotendinous junctions can guide cell differentiation via topographical and mechanical cues. Honeycomb scaffolds induced bone-like differentiation, while aligned fibers promoted tendon fate. A gradient scaffold with three zones (bone, tendon, muscle) supported initial co-culture, though high-proliferation cell lines affected outcomes. Future work involves optimizing scaffold design and using primary or stem cells for full tissue integration.