Kurzfassung: Tendons link muscle to bone, enabling movement, but heal poorly. To improve repair, researchers are developing engineered grafts mimicking bone-tendon-muscle interfaces. Unique structures at entheses and myotendinous junctions can guide cell differentiation via topographical and mechanical cues. Honeycomb scaffolds induced bone-like differentiation, while aligned fibers promoted tendon fate. A gradient scaffold with three zones (bone, tendon, muscle) supported initial co-culture, though high-proliferation cell lines affected outcomes. Future work involves optimizing scaffold design and using primary or stem cells for full tissue integration.
